首頁
瀏覽量: 132
- 產(chǎn)品名稱： Research Grade Ansuvimab（mAb114)
- 產(chǎn)品貨號(hào)： CSD00706
- 貨期： 現(xiàn)貨
- 價(jià)格與訂購： 2480
- 數(shù)量：
庫存： 100
- 規(guī)格： 100μg
- 產(chǎn)品信息
- 如何訂購
貨號(hào)（Catalog No.）
CSD00706
通用名INN
Ansuvimab
純度(Purity)
>95%
電泳圖（SDS-PAGE image）
濃度( Concentration)
1mg/ml
Formulation
PBS buffer PH7.5
Source
XtenCHO
內(nèi)毒素(Endotoxin level)
Please contact with the lab for this information.
生物活性
靶點(diǎn);物種(Specificity target name;species)
GP1 surface protein of Ebolavirus
靶點(diǎn)背景信息(Target information)
Responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into dendritic cells (DCs) and endothelial cells . Binding to the macrophage specific lectin CLEC10A also seem to enhance virus infectivity. Interaction with FOLR1/folate receptor alpha may be a cofactor for virus entry in some cell types, although results are contradictory. Members of the Tyro3 receptor tyrosine kinase family also seem to be cell entry factors in filovirus infection. Once attached, the virions are internalized through clathrin-dependent endocytosis and/or macropinocytosis. After internalization of the virus into the endosomes of the host cell, proteolysis of GP1 by two cysteine proteases, CTSB/cathepsin B and CTSL/cathepsin L presumably induces a conformational change of GP2, allowing its binding to the host entry receptor NPC1 and unmasking its fusion peptide to initiate membranes fusion.
種類(Species)
Humanized
受體鑒定(Receptor identification)
IgG1
化學(xué)信息
分子量(MV)
150000.00 Da
存儲(chǔ)條件(Storage)
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Note
For research use only .
地 址：
產(chǎn)品銷售：
E - mail ：
郵 編：
Amily
