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- 產品名稱： Recombinant Human OTUB1 protein
- 產品貨號： CSP01173
- 貨期： 現貨
- 價格與訂購： 1800
- 數量：
庫存： 100
- 規(guī)格： 50μg 100μg 1mg
- 產品信息
- 如何訂購
概述（Summary）
英文全稱
Recombinant Human OTUB1 protein
純度（Purity）
>90% as determined by SDS-PAGE
內毒素（Endotoxin level）
Please contact with the lab for this information.
蛋白構建（Construction）
A DNA sequence encoding the human OTUB1 (Met1-Lys271) was fused with His tag
Accession #
Q96FW1
表達宿主（Host）
E.coli
種屬（Species）
Homo sapiens (Human)
預測分子量（Predicted Molecular Mass）
31.62 kDa
制劑（Formulation）
Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
運輸方式（Shipping）
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
穩(wěn)定性&儲存（Stability &Storage）
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
復溶（Reconstitution）
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
背景（Background）
背景介紹
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytoplasm protein which belongs to thepeptidase C65 family. OTUB1 is a hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. OTUB1 is a regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. OTUB1 acts via its interaction with RNF128 / GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform1 of OTUB1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform2of OTUB1 stabilizes RNF128 and promotes anergy. OTUB1 regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). OTUB1 mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. OTUB1 is also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin.
分子別名（Alternative Names）
Ubiquitin thioesterase OTUB1,Deubiquitinating enzyme OTUB1,OTU domain-containing ubiquitin aldehyde-binding protein 1,Otubain-1,hOTU1,Ubiquitin-specific-processing protease OTUB1.
Note
For research use only .
地 址：
產品銷售：
E - mail ：
郵 編：
Amily
