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- 產(chǎn)品名稱： Recombinant Human CHRNa7 protein
- 產(chǎn)品貨號(hào)： CSP00295
- 貨期： 現(xiàn)貨
- 價(jià)格與訂購(gòu)： 1800
- 數(shù)量：
庫(kù)存： 100
- 規(guī)格： 50μg 100μg 1mg
- 產(chǎn)品信息
- 如何訂購(gòu)
概述（Summary）
英文全稱
Recombinant Human CHRNa7 protein
純度（Purity）
>90% as determined by SDS-PAGE
內(nèi)毒素（Endotoxin level）
Please contact with the lab for this information.
蛋白構(gòu)建（Construction）
A DNA sequence encoding the human CHRNa7 (Arg118-Tyr227) was fused with His tag
Accession #
P36544
表達(dá)宿主（Host）
E.coli
種屬（Species）
Homo sapiens (Human)
預(yù)測(cè)分子量（Predicted Molecular Mass）
13.27 kDa
制劑（Formulation）
Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
運(yùn)輸方式（Shipping）
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
穩(wěn)定性&儲(chǔ)存（Stability &Storage）
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
復(fù)溶（Reconstitution）
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
背景（Background）
背景介紹
CHRNA7 have been associated with intellectual disability (ID), seizures and neuropsychiatric phenotypes. Decreased expression of CHRNA7, the gene encoding the alpha7( *) subtype of nicotinic receptor, may contribute to the cognitive dysfunction observed in schizophrenia by disrupting the inhibitory/excitatory balance in the hippocampus. The human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously expressed in both the central nervous system and in the periphery. CHRNA7 is genetically linked to multiple disorders with cognitive deficits, including schizophrenia, bipolar disorder, ADHD, epilepsy, Alzheimer's disease, and Rett syndrome. There is a genetic link between CHRNA7 and startle magnitude, indicating that cholinergic neurotransmission involving the alpha7nAChR could be involved in sensory registration processes. The overexpression of CHRNA7 negatively controls colorectal cancer LoVo cell invasion and metastasis via PI3K/Akt pathway activation and may serve as either a diagnostic marker or a therapeutic target for colorectal cancer metastasis.
分子別名（Alternative Names）
Neuronal acetylcholine receptor subunit alpha-7.
Note
For research use only .
地 址：
產(chǎn)品銷售：
E - mail ：
郵 編：
Amily
