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- 產(chǎn)品名稱： Research Grade Dinutuximab ( 地努妥昔單抗 )
- 產(chǎn)品貨號： CSD00319
- 貨期： 現(xiàn)貨
- 價格與訂購： 2480
- 數(shù)量：
庫存： 100
- 規(guī)格： 100μg
- 產(chǎn)品信息
- 如何訂購
貨號（Catalog No.）
CSD00319
通用名INN
Dinutuximab
純度(Purity)
>95%
電泳圖（SDS-PAGE image）
icon
濃度( Concentration)
1mg/ml
Formulation
PBS buffer PH7.5
Source
CHO cells
內(nèi)毒素(Endotoxin level)
Please contact with the lab for this information.
產(chǎn)品描述(Description)
Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of the variable heavy- and light-chain regions of the murine anti-GD2 mAb 14.18 and the constant regions of human IgG1 heavy-chain and kappa light-chain. By binding to GD2, dinutiximab induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity of tumor cells thereby leading to apoptosis and inhibiting proliferation of the tumour. It is indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy. Despite a high clinical response seen after first-line treatment, the complete eradication of neuroblastoma is rarely achieved and the majority of patients with advanced disease suffer a relapse. Current strategies for treatment include immunotherapy with drugs such as dinutuximab to target surviving neuroblastoma cells and to prevent relapse.
別名(Alternative names)
14.18,MAb-14.18,MOAB Ch14.18
靶點;物種(Specificity target name;species)
ganglioside GD2[Homo sapiens]
種類(Species)
Chimeric
受體鑒定(Receptor identification)
IgG1-kappa
分子量(MV)
145000.0 Da
CAS
1363687-32-4
存儲條件(Storage)
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Note
For research use only .
地 址：
產(chǎn)品銷售：
E - mail ：
郵 編：
Amily
