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- 產(chǎn)品名稱： KL-11743
- 產(chǎn)品貨號： CS01459
- 貨期： 現(xiàn)貨
- 價格與訂購： 1500
- 數(shù)量：
庫存： 10
- 規(guī)格： 5mg
- 產(chǎn)品信息
- 如何訂購
產(chǎn)品描述
KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death[1][2][3].
分子量
522.60
分子式
C30H30N6O3
結(jié)構(gòu)式
CAS No.
1369452-53-8
性狀
固體
顏色
Light yellow to green yellow
純度
98%
運輸條件
Room temperature in continental US; may vary elsewhere.
儲存條件
Powder: -20°C for 3 years，4°C for 2 years ；In solvent: -80°C for 6 montha，-20°C for 1 month|.
參考文獻
[1]. Liu KG, et, al. Discovery and Optimization of Glucose Uptake Inhibitors. J Med Chem. 2020 May 28;63(10):5201-5211.
[2]. Liu X, et, al. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020 Apr;22(4):476-486.
[3]. Olszewski K, et, al. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2021 Oct 22;S2451-9456(21)00441-4.
Note
For research use only.
上一篇 SR17018
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Amily
