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- 產(chǎn)品名稱(chēng)： Pomiferin 橙桑黃酮
- 產(chǎn)品貨號(hào)： CSN4315
- 貨期： 現(xiàn)貨
- 價(jià)格與訂購(gòu)： 2400
- 數(shù)量：
庫(kù)存： 5
- 規(guī)格： 5mg
- 產(chǎn)品信息
- 如何訂購(gòu)
生物活性
Pomiferin (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 μM).
IC50 & Target
HDAC：1.05 μM (IC50)
mTOR：6.2 μM (IC50)
mTOR：6.2 μM (IC50)
體外研究(In Vitro)
Pomiferin is an potential inhibitor of HDAC, with an IC50 of 1.05 μM. Pomiferin shows cytotoxic effects on human tumor cell lines, with GI50s of 1.32 ± 0.02 μM (HCT-15 cells), 2.92 ± 0.09 μM (MDA-MB-231 cells), 3.18 ± 0.05 μM (ACHN cells), 3.34 ± 0.11 μM (LOX-IMVI cells), 3.95 ± 0.05 μM (PC-3 cells), 5.14 ± 0.06 μM (NCI-H23 cells), and 123 μM (Hepatocyte cells)[1]. Pomiferin is a highly specific mTOR inhibitor, with an IC50 of 6.2 μM. Pomiferin triacetate only affects two PI3Kα mutants, E542K and E545K. Pomiferin triacetate (0.3125-20 μM) stabilizes Pdcd4 from TPA-induced degradation in HEK293 cells. Pomiferin triacetate (20 μM) inhibits IGF-1-induced signaling downstream of Akt activation[2].
體內(nèi)研究(In Vivo)
Pomiferin (5, 10 and 20 mg/kg, p.o.) shows protective effects on the treatment of reperfusion injury. Pomiferin also increases SOD activities and total antioxidative capacity, and decreases malondialdehyde in rats[3].
分子量
420.45icon
性狀
固體
Formula
C25H24O6
CAS 號(hào)
572-03-2
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中文名稱(chēng)
橙桑黃酮
結(jié)構(gòu)分類(lèi)
PhenolsPolyphenols
初始來(lái)源
植物桑科橙桑
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CAS 號(hào)
1955-26-6
儲(chǔ)存方式
Powder-20°C 3 years，4°C 2 years；In solvent -80°C 6 months -20°C 1 month
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參考文獻(xiàn)
[1]. Son IH, et al. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4753-5. [Content Brief]
[2]. Bajer MM, et al. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol. 2014 Apr 1;88(3):313-21. [Content Brief]
[3]. Barto?íková L, et al. Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats. Interdiscip Toxicol. 2010 Jun;3(2):76-81. [Content Brief]
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純度
97.36%
Note
For research use only .
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