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- 產(chǎn)品名稱： Sibiromycin
- 產(chǎn)品貨號： CS00007
- 貨期： 現(xiàn)貨
- 價格與訂購： 3000
- 數(shù)量：
庫存： 10
- 規(guī)格： 1mg
- 產(chǎn)品信息
- 如何訂購
產(chǎn)品描述
A naturally produced glycosylated pyrrolobenzodiazepines
生物活性
Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine[1][2].
體外研究(In Vitro)
Pyrrolobenzodiazepines (PBDs) are sequence selective DNA alkylating agents with remarkable antineoplastic activity[1].
Alkylation of DNA by anthramycin, sibiromycin and tomaymycin is sequence specific with the following trend for binding preference 5′-Pu-G-Pu>5′-Py-G-Pu>5′-Pu-G-Py>5′-Py-G-Py[1].
Sibiromycin shows cytotoxicity against L1210 (leukemia), ADJ/PC6 (plasmacytoma) and CH1 (ovarian) cells with IC50s of ranging 0.000017 ~0.0029 μM[1].
(We have not independently confirmed the accuracy of these methods. They are for reference only.)
別名
西伯利亞霉素
純度
95%
分子量
475.53
分子式
C24H33N3O7
CAS No.
12684-33-2
運輸條件
Room temperature in continental US; may vary elsewhere.
儲存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
參考文獻(xiàn)
[1]. Gerratana B. Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev. 2012;32(2):254-293.
[2]. Li W, et al. Biosynthesis of sibiromycin, a potent antitumor antibiotic. Appl Environ Microbiol. 2009;75(9):2869-2878.
Note
For research use only .
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