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  • 產(chǎn)品名稱: SR8278
  • 產(chǎn)品貨號(hào): CS7837
  • 貨期: 現(xiàn)貨
  • 價(jià)格與訂購(gòu): 960
  • 數(shù)量:
    庫(kù)存: 100
  • 規(guī)格: 1mg 10mg 1g
  • 產(chǎn)品信息
  • 如何訂購(gòu)
    產(chǎn)品描述
    SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 
    靶點(diǎn)活性
    REV-ERBα
    體外活性
    SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells[1] 
    參考文獻(xiàn)
    1. Kojetin D , Wang Y , Kamenecka T M , et al. Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB[J]. Acs Chemical Biology, 2011, 6(2):131-134.2. Dong D , Sun H , Wu Z , et al. A validated ultra-performance liquid chromatography-tandem mass spectrometry method to identify the pharmacokinetics of SR8278 in normal and streptozotocin-induced diabetic rats[J]. Journal of Chromatography B, 2016, 1020:142-147.
    純度
     99.44%
    分子量
    361.48
    分子式
    C18H19NO3S2
    CAS No
    1254944-66-5
    存儲(chǔ)
    0-4℃ for short term (days to weeks), or -20℃ for long term (months).
    溶解度
    DMSO: 10mg/ml(27.66mM)
    ( < 1 mg/ml refers to the product slightly soluble or insoluble )
    icon
    Note
    For research use only .
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